Use of Botox in Urology

What is Botox?

The toxin (neurotoxin) of the bacterium Clostridiu Botulinum, which causes food poisoning, inhibits the release of acetylcholine in the muscles and shows its effect by partial paralysis.

Uses of Botox in urology

1-Incontinence, interstitial cystitis and bladder pain syndrome

In urology, urinary incontinence, overactive bladder, neurogenic bladder, interstitial cystitis and bladder pain syndrome are also used successfully as an alternative to medication or inconsistent with medical treatment. Before deciding on the application, it should be ensured that there is no bladder cancer. By diluting the Botox material, it is applied systematically to the bladder muscle at 20-30 different points, in a total dose of 100 to 300 units, under local or general anesthesia by means of an endoscope (cystoscope).

2-Botox application in prostate enlargement

It is seen as an effective and safe method in patients who have urinary problems due to prostate enlargement, who do not benefit enough from alternative drug treatment or drugs, and in some selected patients who are not suitable for surgery. This method is not a standard and routine method used in the treatment of prostate enlargement. The procedure refers to the injection of 100-300 Units of Botox material, depending on the size of the prostate, under local or general anesthesia, with a needle of appropriate length under the guidance of rectal, transurethral (through the urinary canal via cystoscope) or perineal (the area between the testis and anal) ultrasonography, especially in a few areas close to the outside of the prostate. it does.

As a result, the given material has the same effect as the drugs called alpha-blockers given to patients for prostate complaints. The procedure has some side effects, among them; painful urination, urinary obstruction, urinary tract infection, allergic reactions. In case of hypersensitivity to Botox, also called Freys syndrome, more careful and lower doses should be used. The toxic dose range in humans is 2500-3000 Units, this dose should not be exceeded.

Conditions in which Botox should not be used

  • pregnancy and lactation,

  • Those who use some drugs that affect the muscles (aminoglycoside, penicillamines, calcium channel blockers, magnesium, cyclosporine)

  • Patients with muscle disease (ALS, Myasthenia gravis, Eaton-Lambert Syndrome)

  • Patients with bleeding disorders (hemophilia etc.)

  • Patients with Botox allergy

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