Patients should start preventive strategies in their early thirties to reduce the risks of skin aging. Early detection of patients at risk of skin aging and effective countermeasures in the early period are important. Functional foods and “nutraceuticals”, which are the ingredients of all foods, have medical effects on health. According to international analysis, 70% of adults all over the world use vitamin, mineral or food supplements. Interest has been concentrated on anti-aging food supplements, and anti-oxidant oral supplements form the most popular group. These;
1. Botanical carotenoids or polyphenols
4. Co-enzyme Q10
7. Omega-3 fatty acids
8. Collagen peptides and hyaluronic acid
β-carotene: Herbal carotenoids are used in the treatment of sunburn reduction with provitamin A (retinol) activity. While the FDA recommends a maximum dose of 300 mg/day, this supplement improves facial wrinkles and skin elasticity and has an anti-photoaging effect.
Astaxanthin Xanthophyll is a carotenoid found in marine organisms and is responsible for the red color of shrimp-lobster. It can have a strong anti-inflammatory effect and improve facial elasticity and skin barrier integrity.
natural polyphenols or flavonoids,It is not just a herbal pigment, it is a powerful anti-oxidant.
Resveratrol: As a minor polyphenol compound, it is found in grape skin, nuts, fruits and red wine. It has anti-cancer properties with anti-inflammatory effect. It has poor absorption and is safe to use up to 5 grams/day. It strengthens the immune response and provides anti-cancer power.
Tea Polyphenols: It has been shown to increase skin barrier function, reduce sun-related skin damage.
Soy isoflavones ; As a well-known anti-aging agent, it shows a chemical structure similar to estrogen. It causes less wrinkles and increased collagen production against sunlight and prevents collagen breakdown. In humans, 12 weeks of isoflavone aglycone supplementation can reduce facial fine wrinkles.
chlorophyll extract The supplement corrects facial wrinkles and elasticity. It prevents wrinkles and DNA damage with its antioxidant properties.
Aloe vera: The pulp of this tropical cactus, which belongs to the lily family, has anti-inflammatory, wound-healing, moisturizing, anti-bacterial, anti-fungal and antiviral properties. Dietary aloe vera gel supplementation (low dose, 1,200 mg/g; high dose, 3,600 mg/g) may improve facial wrinkles and elasticity. The polysaccharides it contains are immune-stimulating. The acetylated glucomannan, acemannan it contains, as a biologically active, dominant polysaccharide, increases collagen biosynthesis.
Vitamin C (ascorbic acid), is the major water-soluble endogenous antioxidant; It regenerates vitamin E in cell membranes and is essential for collagen synthesis. In daily doses of 500 mg-6 gr, it lowers blood pressure and reduces the period of infection.
Vitamin E ( α -tocopherol), It is found in cell membranes and circulating lipoproteins as a lipid-soluble antioxidant. It strengthens immune functions and reduces infection rates in the elderly. For its systemic sunscreen effect, up to 800 mg/day can be used harmlessly.
panax ginseng Its roots have been used as a general tonic in Far Eastern medicine for thousands of years. Red ginseng is prepared by steaming and air drying and is more biologically active than white ginseng that is peeled and dried. Red ginseng has anti-oxidant, immunostimulating and anti-aging activity, and provides collagen increase with reduction in facial wrinkles.
squalene , as a polyunsaturated aliphatic hydrocarbon, is abundant in shark liver oil. Oral squalene supplementation at 27 g/g (high dose) can reduce facial wrinkles and sun-related damage.
honey bee milk Its lipid contents are mainly medium-chain aliphatic fatty acids, which increase collagen production. 10-hydroxy-2-decenoic acid, as a characteristic ingredient of honey bee milk, stimulates collagen synthesis.
Eicosapentaenoic acid (EPA) and other omega-3 fatty acidsConsumption of 4-10 gr/g provides protection against sun-related skin damage.
Oral hydrolyzed collagen peptidesupplement (2.5 gr/g and 5.0 gr/g for 8 weeks) increases skin elasticity and provides moisturization.
Proteoglycans: As a complex family of macromolecules, they contain core protein and covalently linked glycosaminoglycans. It prevents sun-related skin aging by reducing redness and water loss.
Oral supplements of carotenoids, polyphenols, chlorophyll, aloe vera, vitamins C and E, red ginseng, squalene, and omega-3 fatty acids are recommended for skin aging. Collagen peptides and proteoglycans can help build new skin. Physicians also need to educate the patient about skin aging when prescribing a food supplement with topical sunscreen cream and retinoids. Daily sunscreen cream with SPF 15 and above, topical retinoid at night, and oral or local antioxidants are the minimum requirements for anti-aging. It is necessary to combine them with cleansing, moisturizing and products such as hydroxy acids, growth factors, heparan sulfate and defensin, and decide according to the patient’s skin type, dryness, inflammation status and melanocyte activity.