NEW CAUSE OF HIGH PLASMA TRIGLYCERIDES DISCOVERED
Hypertriglyceridemia is a lipid metabolism disorder resulting from excessive synthesis, defective processing and clearance, or a combination of both. Dietary triglycerides are absorbed from the small intestine and secreted into the lymphatic system. Although most of the triglycerides in the blood are absorbed from the small intestine, the liver also produces some triglycerides and gives them to the blood.
Hypertriglyceridemia, especially recently CVDdetermining that it is a risk factor in itself for the development of acute pancreatitis and non-alcoholic (non-alcoholic) steatohepatitis (fatty liver) Knowing that it plays an important role in the development of the disease reveals the necessity of treatment. Hypertriglyceridemia is mostly caused by uncontrolled diabetes, uncontrolled sugary foods, high fructose intake and obesity. Elevated plasma triglyceride levels can also be caused by mutations in various genes that regulate triglyceride metabolism. However, despite years of research and an increasing understanding of triglyceride metabolism, most cases of hypertriglyceridemia are not fully understood.
We always advise individuals with high triglyceride levels to diet, exercise, and avoid high-fat foods. However, this did not affect some patients and the reason was not revealed. In a study by the University of California, researchers ‘GPIHBP1 autoantibody syndrome’They argue that a syndrome called hypertriglyceridemia is a significant advance.
Triglycerides in the blood circulation are broken down by enzymes called lipoprotein lipase in the capillary. GPIHBP1autoantibodies against triglyceride cleavage (digestive)It has been observed that by inhibiting the activity of lipoprotein lipase, it prevents the digestion of triglycerides.
Scientists, GPIHBP ‘detected 6 people with autoantibodies against the virus and one of them became pregnant. These harmful autoantibodies were formed in the baby by passing through the placenta of the pregnant person and entered the baby’s circulation. As a result, severe triglyceride elevation in the baby (hypertriglyceridemia)Triglyceride levels in the baby returned to normal after the mother’s harmful autoantibodies disappeared.
Researchers, GPIHBP1More research will be needed to define the frequency of autoantibody syndrome and how it can be treated, but they said that immunosuppressive drugs can help reduce autoantibodies and lower plasma triglyceride levels.
Deputy chief of atherothrombosis and coronary artery disease at the National Heart, Lung and Blood Institute, Dr. Michelle Olive, “Researchers not only discovered a new disease, their findings suggested it was treatable”said. “These findings are the result of years of NHLBI-funded research into the molecular mechanisms of GPIHBP1 and are an excellent example of how basic science can lead to scientific advances with direct clinical implications.”They said.