IVF treatment – metabolomics

The selection of the best embryo to be transferred in IVF treatment remains the most important issue from the very beginning. One of the latest developments in this subject, which is constantly open to innovation, is that, besides the standard methods currently used, if the embryo is accepted as a living organism, its metabolism works and by using these two methods together, it gets a little closer to choosing the best embryo. omics technologies.

The selection of the best embryo, which will still be widely transferred and therefore with the highest pregnancy potential, is made according to the morphological grading result made by looking at the external morphological images of the embryos. Of course, embryo selection has a certain value morphologically. However, it has been shown in genetic studies that 50-60% of these embryos can carry genetic defects in the case of choosing embryos with the highest quality morphological criteria. For this reason, it can be said that choosing embryos only according to morphological-external appearance criteria is not the most appropriate method, and there should be new scientific methods that will allow more objective selection. At this stage, we can talk about metabolomics studies, one of the new omics technologies today.

Embryos are in constant interaction with the culture fluids they are in during IVF treatment. Like all living organisms, the embryo, which is actually a living organism, has a metabolism. The embryo takes the molecules it needs from the culture liquid it is in and metabolizes it and returns the metabolites formed after use to this liquid medium. Here in metabolomics technology; A sample is taken from this culture liquid in which the embryo is located, light is passed through the liquid at different wavelengths with biospectroscopic techniques, and map samples are created depending on the state of the metabolites in the content. Since the metabolism of each embryo is different, the content of the fluid it is in will also be different, so the map obtained after metabolomics will also be different. These map samples obtained and which are different for each embryo, provide information about the development and pregnancy capacity of that embryo. It has been determined that this technique, called Metabolomics technology, can provide more objective information about the embryo in addition to the morphological criteria used in the studies. As a matter of fact, metabolism-based metabolomics studies carried out in embryos with the best morphology and therefore thought to give the highest chance of pregnancy; shows that these embryos are not at all embryos with high pregnancy potential as expected.

As the knowledge on this subject increases in the future, it can already be said that metabolomics studies may enter the routine and become one of the most important laboratory techniques to increase pregnancy rates.

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