Genetic Translocation Solution with IVF

Gynecology, Obstetrics and IVF Specialist Op. Dr. Seval Taşdemir explained the applications about translocation solution and IVF treatment for you.

Genetic factors are one of the most important causes of miscarriage. There are 46 (23 pairs) chromosomes in each cell of individuals. 23 of these chromosomes come from the mother and 23 from the father. Cells contain 22 pairs of autosomal chromosomes and 1 pair of sex chromosomes. Men have one X and one Y sex chromosomes, and women have two X sex chromosomes. Before fertilization, the chromosomes in egg and sperm cells are reduced to half (23 pieces) by meiosis. An embryo containing 46 chromosomes is formed by the union of the egg and sperm cell, which is called fertilization. Problems occurring at this time lead to anomalies in the number of chromosomes.

Translocation: Incorrect chromosome sequence

Another chromosomal disorder is translocation, in which the chromosome number is normal but the sequence is incorrect. When there is a translocation in the mother or father, this does not cause any health problems in the mother or father, but an imbalance in the genetic information distribution may occur during egg or sperm formation. This situation is determined by the chromosomal examination to be made to the mother and father-to-be.

If the mother or father is a carrier of a balanced translocation, the child may be born with some degree of physical and learning disability, depending on the type of chromosomes involved and exactly how much chromosomal material is missing or extra.

Couples who have had two or more miscarriages can find out if they are translocation carriers by having a chromosome test. A simple blood test can determine whether a person is a translocation carrier or not. Translocation is inherited from the mother or father or occurs during fertilization. The translocation cannot be corrected and persists throughout life. Balanced translocation carriers can have healthy children.

This situation can be controlled with IVF treatment.

The child born to a mother or father who is a carrier of translocation may be completely healthy or disabled as a result of unbalanced translocation. When conceived naturally, the health of the child is left to chance. However, embryos created by in vitro fertilization are examined with PGD (Preimplantation Genetic Test). Healthy embryos are selected and transferred. Thus, couples can have healthy children.

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