Damage to the inner lining of the uterus and in vitro fertilization


In some clinical studies conducted in recent years, it has been shown that biopsy taken from the uterus may have a positive effect on the retention rates of embryos in IVF treatments.
Researchers have attempted to explain the underlying mechanism as a positive reaction induced by injury.
According to the article published in Fertility & Sterility, one of the important journals in the field of reproductive problems, the increase in the levels of macrophage inflammatory protein 1B (MIP-1B), a protein that may have an important role in the attachment of the baby to the mother’s womb, was evaluated as a support for pregnancy.
Yulia Gnainsky et al. conducted a study to determine the mechanism underlying the positive effect of intrauterine insertion procedure on pregnancy formation in patients who had failed previous in vitro fertilization attempts. They took a sample from the uterus on the 21st day of menstruation from the control and study groups. 8 and/or 11-13 of the same period. In the last days, parts of the uterus were also taken from the groups.
The findings of the study are as follows:
Increase in the number and levels of some molecules and cells (such as macrophage/dendritic (HLA-DR+CD11c+), tumor necrosis factor-alpha, interleukin -15, proinflammatory cytokines, macrophage inflammatory protein 1B) known to have an important role in the attachment of the baby in the intrauterine samples of the experimental group observed.
The increase in these molecules is known to be positively related to the course of pregnancy.
Based on these findings, it was concluded that intrauterine sampling has a facilitating effect on the preparation of the uterus for pregnancy. The same team, in their study published in Fertil-steril in 2009, showed that taking intrauterine samples modulates the protein production of some genes.
Other researchers (Li and Hao) have noted that removing polyps (a piece of intrauterine flesh) and thickened uterine lining 2 weeks before embryo transfer increases the chances of successful pregnancy in IVF patients. Researchers emphasized the possible positive effect of local intrauterine injury (injury) on embryo attachment rates in IVF patients.
However, not every intrauterine damage has a positive effect, of course. The timing of this effect is very important. Karimzade et al., in a randomized controlled study they conducted last year, showed that local intrauterine damage created during IVF treatment, but not before, on the day of egg collection, significantly reduced embryo retention rate, clinical and ongoing pregnancy rates. Intrauterine damage impairs the sensitivity of the inner wall of the uterus and therefore has a negative effect on the course of IVF treatment.
Therefore, the damage to the uterus is approximately 3rd of the previous period.
week seems to give the most beneficial results.
Further studies are expected to definitively confirm this positive effect resulting from intrauterine damage in IVF treatment.

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