Choriocapillaris signal spaces in patients with diabetic retinopathy

SUMMARY Objective: To evaluate the choriocapillaris flow areas using the optical coherence tomography angiography (OCTA) flow assessment tool in patients with non-proliferative diabetic retinopathy (NPDRP) and compare them with healthy individuals. Material and Methods: In this retrospective study, patients who were followed up for very mild, mild and moderate NPDRP in the retina unit of our clinic according to the diabetic retinopathy early treatment study and patients who applied to the general outpatient clinic for routine eye examination were evaluated. Best corrected visual acuity, anterior and posterior segment examinations, intraocular pressure, axial length, central corneal thickness and refractive error measurements were recorded. At the same time, spectral domain optical coherence tomography (SD-OCT), fluorescein angiography and OCTA imaging were performed. All OKTA images were performed using the AngioVue software of the RTVue XR Avanti device (Opto-Vue, Inc., Fremont, CA, Version 2017.1.0.151) and taking 6×6 images. With the flow evaluation tool of the device, the flow area of ​​the choriocapillaris was calculated in the regions within the fixed circles of 1 mm, 2 mm and 3 mm radii, the central foveal avascular zone (FAZ). Results: Thirty eyes of 30 patients (21 females and 9 males) were studied as the study group, and 30 eyes of 30 healthy subjects (20 females and 10 males) were examined as the control group. The mean age of the study and control groups was 58.82±3.50, and 57.65±5.84 years, respectively. In the OCTA measurements, the choriocapillaris flow areas in all three radius areas of the group with NPDRP were found to be statistically significantly lower than the control group. (p=0.004, p=0.004 and p=0.008, respectively). Conclusion: In conclusion, this study was performed using optical coherence tomography angiography as the imaging method and showed that the choriocapillaris flow area is lower in patients with NPDRP than in healthy individuals.

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