acanthosis nigricans

We know that the prevalence of obesity is increasing in the whole world population with a sedentary lifestyle and fast food diet. And also; Along with the hormonal changes that women experience in a period of their lives, the changes that occur in the systems in our body may have reflections on the skin. One of them is ”Acanthosis Nigricans”.

What is this skin change observed in our patients who applied with the complaint of darkening and then swelling in many areas such as the armpit, groin, under the breast, abdomen fold, knee-elbow parts?

Acanthosis Nigricans, as the name suggests, means black (nigra means black, dark) skin thickening (acanthosis).

It is an epidermal disorder that most commonly causes thickening and darkening of the neck, armpits, groins and other folds of the body. Accompanying acrochordon structures called flesh-and-peel can often accompany the neck and underarm areas.

There are 5 different types:

Type 1: Hereditary type occurs structurally without any disorder

Type 2: associated with insulin resistance Diabetes is the type associated with endocrine disorders such as acromegaly, Cushing’s syndrome, hypothyroidism, Addison’s disease.

Type 3: Psodo; It occurs due to obesity and having dark skin type. Metabolic syndrome is common. If the patient is obese, insulin resistance may accompany.

Type 4: drug-related; occurs due to the use of cortisone or some hormone drugs

Type 5: malignant type; It is the type that can usually accompany cancers. The onset is particularly sudden and severe. Even; They can affect areas different from common areas such as palms and around the mouth.

acanthosis nigricans; In the picture of the disease, darkening of the skin color occurs first in the involvement areas, and the skin appears as if it is dirty. The skin thickens and acquires a velvety consistency. In time; skin lines become clear and its surface starts to become rough and protruding.

What do we do in patients with the lesions described?

First of all, are there any complaints that will cause the endocrine disorders mentioned above? should be questioned. These:

**Acne, hair growth, menstrual irregularity or amenorrhea, obesity, hair loss, striae called cracks and weight loss for malignant type, change in bowel habits. Patients with this complaint, accompanied by Acanthosis Nigricans, should be evaluated with necessary tests and directed to the relevant branches for their complaints.

What do we do in the treatment of skin lesions?

Acanthosis nigricans lesions; It can be treated with a controlled wound healing process by performing skin peeling with ablative lasers such as fractional CO2 laser application (after the treatment if there is an underlying disorder).

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